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doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois

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In addition to having to overcome the IGF-1/IGFBP complex issues, the IGF-1 analytical techniques have recently had to contend with the existence of therapeutic forms of IGF-1

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B12 Deficiency and MTHFR: Individuals with MTHFR mutations may also be more prone to Vitamin B12 deficiencies