Experiments in islet cell models have shown that intracellular signalling after GLP-1R agonist binding occurs via two pathways, one of which (cyclic adenosine monophosphate generation) enhances insulin release, while the other (-arrestin recruitment) causes GLP-1R receptor internalisation, and hence reduces cellular sensitivity to ligand
Hyperandrogenism is associated with earlier age of onset of idiopathic intracranial hypertension in women
These agents can be carefully initiated and titrated by cardiologists, with limitations and adverse effects under consideration
Genetic disruption of the Gipr in Apoe / mice promotes atherosclerosis
Neither renal composite 1 (40% eGFR decline, RRT, or renal death) nor composite 2 (composite 1 variables plus macroalbuminuria) was reduced by exenatide in unadjusted analyses
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