In its natural context, this protein appears to play a role in the stomach's remarkable ability to: Maintain mucosal integrity despite constant acid exposure Rapidly repair minor daily damage to the stomach lining Protect against ulcer formation Coordinate healing responses after injury The synthetic BPC-157 peptide is more stable than the natural compound, allowing for consistent production and research applications
Leyden J, Stephens T, Finkey MB, Appa Y, Barkovic S
P., Swink, S
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The possible involvement of sensory neurons in the salutary effects of NaBPC157 (10 g/kg, 10 ng/kg i.p.) was studied with capsaicin which has quite distinct effects on sensory neurons: high dose administration to adult animals (125 mg/kg s.c., (subcutaneously) three months of age) or administration (50 mg/kg s.c.) to neonatal animals (seven days of age) destroys sensory fibers, whereas a low dose (500 g/kg i.p.) activates a neurotransmitter release and protective effects on the mucosa
This creates Reactive Oxygen Species (ROS) which generate more oxidative stress