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Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
Despite concerns that GLP-1RAassociated weight loss reduces BMD through mechanical unloading (Wolff's law), a 2025 retrospective cohort of elderly type 2 diabetes patients showed long-term GLP-1RA use was associated with a significantly lower incidence of osteoporosis (HR 0.69)
95% CI 2.1, 5.4%) developed systemic side-effects
Ward DM, Cloonan SM
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