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This enzyme exists in two forms: a membrane-bound version on cell surfaces and a soluble form circulating in the bloodstream

In low-grade dysplasia (LGD) there is cytological atypia up to the mucosal surface (Figure 2), nuclear atypia with hyperchromatism and pleomorphism, increased mitosis, and crowding of glands with decreased intervening lamina propria, but nuclear polarity is preserved

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