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Similarly, Bettini et al

Providers evaluate fasting glucose, lipid panels, and metabolic history to confirm indication

Your provider will evaluate several other factors as well, including: History with weight management, especially prior weight-loss attempts Personal medical history Family medical history Age (only available for adults 18 or older) Semaglutide treatment is not recommended for the following individuals: Pregnant or breastfeeding women Those with a personal or family history of medullary thyroid carcinoma or MEN 2 Other medical conditions may affect whether you qualify for semaglutide

Which is better: semaglutide or tirzepatide

But the results tend to be more durable because the underlying metabolic drivers have changed, not just suppressed

The GIP component adds: Enhanced Insulin Response: Even stronger blood sugar control than GLP-1 alone Better insulin secretion timing Improved insulin sensitivity in tissues Fat Metabolism Effects: GIP receptors exist in fat tissue May influence how body stores and uses fat Potentially increases fat burning Synergistic Appetite Suppression: GIP and GLP-1 together produce greater appetite reduction More potent satiety signals Stronger overall effect This explains why tirzepatide produces 5-7% more weight loss than semaglutidethe dual action is more powerful than GLP-1 alone