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[DOI] [PubMed] [Google Scholar] 51.Ursini F., Maiorino M
These neuropathological changes initiate microglia activation, neuroinflammation, progressive neuronal apoptosis, synaptic dysfunction, impairment of cholinergic neurotransmission, synaptic dysfunction, and the development of cognitive decline in AD (Chen et al
However, patients should avoid overexertion, particularly during periods of rapid weight loss or fatigue
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Collectively, these findings underscore the potential of targeting ferroptosis-related pathways to overcome gemcitabine resistance in patients with PDAC