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10.3389/fnagi.2017.00220 [DOI] [PMC free article] [PubMed] [Google Scholar] Vadini F., Simeone P., Boccatonda A., Guagnano M., Liani R., Tripaldi R., et al

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While the pro-inflammatory effect of microcrystalline UA is well-established 3,20 , there are several indications that soluble UA free of UA crystals has protective effects against inflammatory mechanisms and toxicity 50 with effects on macrophage polarisation towards the anti-inflammatory M2 phenotype 51

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