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However, in a large study involving people with diabetes who had no comorbidities, GLP-1 RAs were not shown to increase the risk of developing pancreatitis at any time point up through 5 years of use.[ref][ref][ref][ref] The Cleveland Clinic now counsels that GLP-1 RA patients should be screened for pancreatitis risk factors, and a lower dose should be used to reduce the risk of pancreatitis.[ref] Related article : Pancreatitis and Genetic Risk Factors Gastroparesis: Case reports tie semaglutide to a risk of gastroparesis (very slow stomach emptying)
GLP-1 RAs enhance or mimic the same functions in the body
Meier JJ, Granhall C, Hoevelmann U, et al
Mabilleau G, Bouvard B
However, its important to note that both Semaglutide GLP-1 and Liraglutide can cause gastrointestinal side effects, with a slightly higher incidence in patients taking Semaglutide GLP-1
A retrospective analysis of 461,382 adults treated with GLP-1 receptor agonists found that nutritional deficiencies were diagnosed in 12.7% of patients within six months and 22.4% within twelve months, with vitamin D deficiency the most common at roughly 13.6% by the one-year mark
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