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Effectiveness and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in type 2 diabetes: an Italian cohort study

Early data can look promising, but benefits in a trial depend on participant selection, monitoring, adherence, dose assignment, and follow-up length

Beyond weight loss, GLP-1 RAs show promise for cardiovascular disease, dementia prevention, mast cells, and immune conditions

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While existing systematic reviews and retrospective cohorts have not identified stable, potent teratogenic signals, the heterogeneity in exposure windows, drug types/dosages, and baseline metabolic riskscompounded by residual confoundingrenders any safe vs