Dai H et al
Given Lillys retatrutide did not reach a weight plateau at the time the Phase 2 study ended, what is the maximum weight loss achievable with longer follow-up
In a pre-specified 104-week study extension tracking individuals with a baseline body mass index (BMI) of 35 or higher, the weight loss trajectory continued, reaching an average reduction of 30.3%equivalent to 85.0 poundsat the 12-milligram dose
Among these, the ketogenic (keto) diet, which peaked in 2020 and subsequently dropped off, has maintained, and even gained popularity for its potential to induce lasting weight loss and improve metabolic health
Finally, its important to note that GLP-1 medications are typically taken as an oral or subcutaneously injected medication (like dulaglutide, sold under the brand name Trulicity) in a single daily or weekly dose
Understanding these variables helps contextualise any changes observed during treatment and prevents unnecessary anxiety