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A trial showed that after 68 weeks on semaglutide: 13.6% did not lose at least5% and can be considered non-responders

These flavor changes occur because GLP-1 signaling alters taste-bud sensitivity and dampens food-reward pathways, not because the medication itself has a taste

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The medication operates as a glucagon-like peptide-1 agonist (GLP-1), GLP-1 is a hormone that plays a role in appetite and digestion, namely in the production of insulin

Free Radic Res 49:228235