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Among them, OPG (decoy receptor for RANKL) blocked the interaction between RANKL (NF-B ligand) and RANK, miR-21-5p downregulated Acvr2a, and let-7b-5p significantly downregulated the expression of osteoclast-related genes, which ultimately inhibited the germination and differentiation of osteoclasts

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Oral administration of GSH is not very effective, however, because it is poorly absorbed through digestion and insufficient amounts cross the blood-brain barrier

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