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Reaching a high research figure typically depends on confirmed tolerance at multiple earlier, lower levels first

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Nonetheless, these clinical trials were underpowered to detect rare events such as suicidal ideation and self-injurious behavior, and they systematically excluded patients with psychiatric comorbidities commonly seen in clinical settings

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But the benefits were mainly seen in people who already had diabetes or more advanced metabolic problems

That's roughly 58 pounds for someone starting at 240 pounds, making it the most effective weight loss medication tested to date