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Activation of -catenin in a genetically engineered melanoma-susceptible mouse model expressing the B-RAFV600E human mutation together with melanocyte-specific Pten loss resulted in uniform melanoma hyperpigmentation and a more aggressive phenotype 44

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Although this approach reliably induces oxidative injury in vitro , it may not fully reflect the chronic and multifactorial oxidative environment of vitiligo

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Central hypothyroidism improves with age in very young children with Prader-Willi syndrome

Castellana M, Cignarelli A, Brescia F, Perrini S, Natalicchio A, Laviola L, et al