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Kinetic assays showed that rifampicin significantly induced CYP3A4 activity in iHLOs over three days, while ketoconazole consistently suppressed CYP3A4 activity over the same period (Fig

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In the dermis, ROS activate signaling cascades such as AP-1 and NF-B, upregulating matrix metalloproteinases (MMP-1, MMP-3, and MMP-9), thereby accelerating type I and III collagen degradation

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This decision is medical and should account for comorbidities, prior weight cycling, and psychological readiness