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The cardiac benefits of GLP-1 agonists were not anticipated before outcome studies were performed for several reasons: (1) Historical Precedent-past experiences with other diabetes medications that unexpectedly had adverse cardiovascular effects made it less likely for researchers and clinicians to anticipate potential cardiovascular benefits without concrete evidence from large-scale trials

But air bubbles are a dosing accuracy issue

Over-the-Counter Remedies : Some patients find relief using OTC anti-nausea medications like meclizine or Dramamine

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Lifestyle & External Influences Stress: raises glucose Exercise: lowers glucose (watch for delayed lows) Alcohol: causes late-night hypoglycemia High-dose Vitamin C or Paracetamol: may distort readings in older sensors Clinical Pearl Two patients with the same HbA1c (7%) can have completely different CGM profiles One stable, the other with repeated highs and dangerous lows

The most commonly mutated genes are the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11), ATP-binding cassette transporter, subfamily C, member 8 (ABCC8), and insulin (INS) genes