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Higher doses increase gastrointestinal side effects without proportional benefits

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Ozempic has not received approval from the Food and Drug Administration (FDA) for the purpose of weight loss

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Notably, GLP-3 also exerted a substantial impact on hepatic steatosis, with liver fat volume reduced by up to 82.4% at 12 mg after 24 weeks

Earlier studies have demonstrated that IL-1 and IL-18 not only promote atherosclerosis progression but also contribute to advanced plaque instability and myocardial infarction (50)