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A controversial 2020 study that claimed the malaria drug hydroxychloroquine showed promise for treating COVID-19 has been retracted, after sparking widespread criticism from scientists ever since its publication

Search Strategy A comprehensive search of PubMed/MEDLINE and the Cochrane Central Register of Controlled Trials (CENTRAL) was performed from database inception through the final search date

A direct head-to-head trial (NCT06662383, 800 patients) is underway with results in December 2026

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However, more recent evidence suggests that sustained supplementation at moderate doses may modestly raise levels over time