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Investigated for MC4-mediated appetite suppression and body-weight effects in preclinical models

Directing therapeutic agents to specific organs or tissues and avoiding unwanted off-target effects continue to challenge the application of laboratory innovations into viable clinical agents

Our findings in the ZSF1 obese rat model provide novel mechanistic insight that aligns with these clinical data

Landmark Clinical Evidence: LEADER, SUSTAIN-6, and REWIND The decisive shift from glucose-centric therapy to cardiorenal risk modification began with three large cardiovascular outcome trials (CVOTs) evaluating long-acting GLP-1 receptor agonists (Table 1, Table 2)

This combination improved measures of cardiovascular health and reduced albumin loss from the kidneys compared with a control group (27)

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