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They found that treatment with metformin in combination with GIMM resulted in lower fasting glucose levels, suggesting better tolerance of metformin therapy for longer or at a higher dosage

10.1001/jama.2010.1275

Along the same lines as ivacaftor and hypertonic saline, several pharmaceutical groups have been pursuing pharmaceuticals that target other ion channels to improve mucociliary clearance in a cftr -independent manner

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When you are not hungry, not eating for 24 hours does not feel like deprivation

PMID 34470787