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Common side effects include: Mild to Moderate Side Effects Nausea Vomiting Diarrhea or constipation Abdominal discomfort Appetite changes Headache Less Common Side Effects: Dizziness Fatigue Injection site reactions Temporary hypoglycemia when combined with other diabetes medications Rare but Serious Side Effects: Pancreatitis: Severe abdominal pain that may radiate to the back Gallbladder disease: Increased risk of gallstones Kidney issues: Worsening kidney function in some patients Thyroid tumors: Observed in animal studies, though human risk is unclear To minimize side effects, we recommend: Important Considerations Before Starting Semaglutide Medical History: Not recommended for individuals with a history of pancreatitis or thyroid cancer

Thus, the ADA's previous recommendation to consider aspirin therapy in women older than 60 years has been changed to include women 50 years and older

Clinical Context Asthma in patients with obesity is often characterized by: More severe symptoms Reduced response to inhaled corticosteroids Increased exacerbation frequency Weight loss has been associated with improved asthma control, but pharmacologic options specifically targeting obesity-related asthma are limited

The Real Risk

senators sent a letter to the FDA raising concerns over a telehealth companys ad about compounded weight-loss medications

Rhew TH & Sachan DS (1986): Dose-dependent lipotropic effect of carnitine in chronic alcoholic rats