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Progesterone reduces wakefulness in sleep EEG and has no effect on cognition in healthy postmenopausal women

In clinical trials, patients experienced an average body weight reduction of 15 to 20 percent over 72 weeks

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So now that you have this cool drug that does both of those things much better than anything else, I suspect we're going to see a lot of improvement, and studies will follow. Fertility is more than body size Even for people without PCOS, weight may play a role in fertility under certain conditions

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For instance, exendin-4 has been shown to ameliorate the high glucose-induced fibronectin (FN) and type I collagen (Col1) expression in tubular epithelial cells by inhibiting the secretion of miR-192, an microRNA (miRNA) that is regulated by p53 and plays a role in renal fibrosis (Li et al., 2018)