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The dosage starts at 2.5 mg once a week and is increased by 2.5 mg every four weeks, up to a maximum dose of 15 mg once weekly

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Factors like aging, environmental stressors, and a lack of specific nutrients can lead to a decline in production

Drugs with very high volumes of distribution have much higher concentrations in extravascular tissue than in the vascular compartment, ie, they are not homogeneously distributed