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Once c-Met receptors are occupied, excess ligand gets cleared without contributing to synaptogenesis

They can be administered with the purpose of the inhibition of tyrosinase activity, reduction of melanin transfer, acceleration of keratinocyte turnover, melanin dispersion, and enhanced skin permeation through the stratum corneum layer (Ortonne, 2006)

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This reduces the UV-induced oxidative stress that triggers melanin production

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