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Advanced disease models, including genetically stratified organoids, patient-derived iPSC lines, and age-appropriate 3D brain cultures, may offer more refined platforms to dissect these differences and identify compound-subtype associations (Sirkis et al., 2022)

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Notably, resveratrol enhanced eNOS promoter activity, particularly within a crucial 263 bp proximal region, while stabilizing eNOS mRNA without altering the binding activity of key transcription factors (Wallerath et al., 2002)