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(p-values: * = 0.05, ** = 0.01, *** = 0.001)

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A positive response was considered quick retraction of the head or scratching of the face with the ipsilateral forepaw

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In a multivariate regression analysis that included changes in GFR, UACR and HbA 1c , we found a significant association between changes in TKV and changes in each of these variables, independent of the other variables