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Smart Image Examples Embodiment 1 [0057] Synthesis of Compound 5: [0058] Weigh 15.97g of 2-chlorotriphenyl chloride resin (sub=0.939mmol / g), add it to a solid-phase synthesis column, use Fmoc-AEEA-OH (1.5eq), DIPEA (4.5eq), solvent DCM, Reaction for 1.5h to obtain Fmoc-AEEA-resin, after synthesis, use 20% piperidine / DMF to deprotect, time: 5+15min

Serious (rare): Severe gastroparesis in patients with existing diabetic gastroparesis

Figure 4 summarizes their key known features and available pre-clinical and clinical information

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The Cys-dependent strategy of NRF2 activation adopted by MSL TNBC cells is all the more interesting as breast cancer is one of the cancers with the lowest number of mutations or copy number variations (CNV) in the KEAP1 , CUL3 or NFE2L2 genes that would lead to constitutive activation of this pathway and are more common in other cancers (Fig

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