In a state of chronic insulin resistance, the biological machinery of muscle building is running at reduced capacity regardless of how much protein a person consumes or how hard they train
It does not reduce overall caloric drive, lower hunger signals, or produce the nausea and food aversion that GLP-1 medications often cause
In terms of tolerability, tirzepatide generally causes fewer gastrointestinal side effects, making it a better option for those sensitive to nausea, while Semaglutide GLP-1 may cause mild to moderate gastrointestinal issues like nausea and diarrhea, which usually subside over time
Ribnicky, D., Poulev, A., Watford, M., Cefalu, W., & Raskin, I
Neurodegener Dis Manag 4(1):3140 Urkon M, Ferencz E, Szsz JA, Szabo MIM, Orbn-Kis K, Szatmri S et al (2025) Antidiabetic GLP-1 receptor agonists have neuroprotective properties in experimental animal models of Alzheimers disease
Under normal digestive conditions, this process is balanced and produces manageable amounts of gas