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In many cases, improper storage is one of the main reasons research compounds fail to perform as expected

doi: 10.3390/biom7020042 84 BartlIOndruovMKumaMJackuliakPGaovAKyseloviJet al

If real interpatient variation in semaglutide response tracks with the proportion of area postrema neurons that sustain versus taper their cAMP response a question that mouse genetics and human imaging could in principle address then the plateau and the non-response phenotypes start to have a concrete cellular address

Impact of Oxidative Stress on the Heart and Vasculature

Nat Rev Endocrinol 8:728742 Rosenstock J, Raccah D, Koranyi L et al (2013) Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X)

These differences are not considered to be clinically meaningful