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The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further

PRP is a relatively quick therapy, as platelets can easily be retrieved from a blood sample

Ideal candidates is anyone with body mass index (BMI) above 30 or with a BMI over 27 and at least one weight-related comorbidity, such as type 2 diabetes, hypertension, or sleep apnea

Now, the difficulty with low B12 levels are that yes, they are more likely to be associated with intestinal problems, but we don't always get overt diarrhea or vomiting with those diseases

The combination remains speculative but represents logical stacking based on mechanism understanding

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