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doi: 10.1371/journal.pone.0293700 74 GongYJiPYangY-SXieSYuT-JXiaoYet al
Luo Z, Eichinger KM, Zhang A, Li S (2023) Targeting cancer metabolic pathways for improving chemotherapy and immunotherapy
The wound healing cascade and GHK-Cu: Normal wound healing occurs in four overlapping phases: Hemostasis clotting Inflammation immune cell recruitment Proliferation new tissue formation Remodeling scar maturation GHK-Cu appears to favorably influence phases 2, 3, and 4 simultaneously: In the inflammatory phase , it reduces pro-inflammatory cytokines (IL-6, TNF-) while preserving necessary immune signaling In the proliferative phase , it stimulates keratinocyte migration and fibroblast proliferation, accelerating epithelial coverage In the remodeling phase , it promotes type I collagen deposition over type III (scar) collagen, leading to better scar outcomes This multi-phase tissue repair activity makes GHK-Cu a compound of interest when studied alongside other regenerative peptides
Patients with cancer are used to experiencing negative symptoms related to life-prolonging treatments and therefore resilient towards the appearance of even disturbing symptoms
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