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M., Bieber, P

GLP-1 receptors have been found on spinal cord microglia, which are the brain and spinal cords immune cells, and activation of those receptors appears to shift microglia from a pro-inflammatory M1 state to an anti-inflammatory M2 state [2, 16]

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Research has associated GLP-1 medications with a higher risk of bowel obstruction compared to other weight loss drugs

Some studies have shown worsening of mental health conditions

Shaking creates harsh mechanical forces that can shear and denature the delicate peptide chains