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Fatigue during the loading phase this comes from TB-500 and your body's systemic repair kicking in

Effects of Candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme

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Citation: Vukojevi, J., Kolenc, D., Brcic, I., & Seiwerth, S

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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs