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At the highest doses, retatrutide seems to promise more significant weight loss than existing GLP-1s on the market but as dosage increases, so does the risk of side effects, mostly mild-to-moderate gastrointestinal issues, although one case of pancreatitis occurred in a patient on the 12mg dose during the phase II trial

El-Osta H, Falchook G, Tsimberidou A, Hong D, Naing A, Kim K et al

Guidelines may vary depending on the area being treated

You lose the benefit of the intact molecule

Technical Specifications Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2 Molecular Weight: 711.9 g/mol Storage: Store at -20C (lyophilized) or 2C8C (reconstituted)

How GLP-1 Medications Impact Digestion GLP-1 (glucagon-like peptide-1) medications mimic the action of a natural hormone in the body that regulates insulin production, decreases appetite, and slows gastric emptying