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Oral bioavailability of AOD-9604 has not been formally quantified in humans
Manuel Serrano, a researcher at the Institute for Research in Biomedicine in Spain during the time of the study who has recently moved to Altos Labs in the United Kingdom and co-lead author of this study, they decided to study the impact of vitamin B12 on cellular reprogramming and tissue regeneration after an unexpected finding when they analyzed how the microbial populations of the colon change during reprogramming
For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation
The Annals of Pharmacotherapy , 46 (2), 240247
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