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patients and healthcare providers, despite warnings issued in Europe and Canada

Any compounded GLP-1 preparation under 503A must comply with applicable federal and state restrictions, including limits on compounding products that are essentially copies of commercially available FDA-approved drugs

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Indeed, gut bacteria play a central role in this metabolic framework by expressing BSH and downstream enzymes that deconjugate primary bile acids (synthesized from cholesterol in the liver) and transform them into secondary bile acids, profoundly modifying their physicochemical properties, intestinal reabsorption, and receptor signaling (80)