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In autoimmune diseases such as systemic lupus erythematosus (SLE), mitochondrial damage and the release of mitochondrial DNA (mtDNA) into the cytoplasm and extracellular space have been observed [130]

Current disclosed candidates in nonclinical and clinical development Recently, chemical advancements of peptides and small molecules and an increased understanding of the melanocortins restored pharmaceutical interest in the development of MC agonists after the underwhelming trials of the early 2000s

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