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The absence of labelling in vacuoles demonstrates that GSH-metal complexes, which are not recognized by the present immunohistochemical approach, are sequestered to this compartment after complexation in the cytosol

This can complement other therapeutic approaches and contribute to a more comprehensive management plan

This trial specifically targeted the thin, delicate skin around the eyes, an area prone to early aging signs

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*Correspondence: Changgang Sun, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers