Functional brain imaging studies have reported a decrease in synaptic connectivity and neuronal circuitry in the PFC and hippocampus in depressed patients (Perlman et al., 2012
However, anti-obesity medications are prescribed to only about 4% of eligible people due to concerns about safety or effectiveness, lack of health care provider training in weight management, excessive costs due to insurance companies refusing coverage, and a toxic stigma that portrays obesity as a lack of willpower
This doesnt mean GLP-1s arent valuable products
Provide transient satiety to decrease food intake 2
Individual experiences vary
High blood sugar has been linked to increased inflammation, so by improving metabolic health, the medication might help reduce inflammatory conditions like arthritis