Individual variation matterssome patients may tolerate longer intervals better than others, particularly if they have genetic variations in GLP-1 receptor sensitivity
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This is particularly relevant given that obesity and T2DM themselves are risk factors for pancreatitis.44,45 Additionally, the prescription of GLP-1RAs is often associated with poor glycaemic control, which could be caused by occult pancreatic diseases.46,47 The treatment selection process introduces intrinsic sources of imbalance and confounding, leading to potential distortions in the results
