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Lincoff et al., 2023, PMID: 37952131) and tirzepatide 15mg (20.9% at 72 weeks) by clinically meaningful margins

It describes the severe damage of cholinergic neurons in the nucleus basalis of meynert (NBM), leading to a marked decrease in choline acetyltransferase (ChAT) activity within the primary projection areas - the cerebral cortex and hippocampus (regions associated with learning and memory)

And, obviously, this is exactly what Vetmedin's manufacturer must want to happen

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Der Fettanteil des Krpers verndert sich nicht

New York, US: McGraw-Hill Medical