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Persistent hyperglycaemia in DM leads to excess production of reactive oxygen species (ROS), instigating testicular damage and resulting in lower fertility []

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The authors identified future areas of investigation including male models, long-term treatment effects, and combination with other NAD+ precursors such as NMN

Yes survodutide is engineered as a single molecule that activates both GLP-1 and glucagon receptors simultaneously, eliminating the need for separate compounds in research protocols targeting both pathways