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A recent clinical trial found that adding the glucagon-like peptide 1 (GLP-1) drug tirzepatide to the biologic ixekizumab helped 30 percent of adults with active psoriatic arthritis (PsA) who had overweight or obesity better control their symptoms while also losing weight

With the recognition that adult humans also have BAT, an organ with substantial capacity to dissipate energy, BAT gained considerable interest as a novel target to treat or prevent obesity and its associated diseases

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With respect to glycolysis in obese adipocytes, a decrease in glucose 6-phosphate accompanied by increased intracellular glucose levels was observed, which implied hexokinase as a possible major rate-limiting step in the provision of glucose carbons required for TG synthesis [32]

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