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Indeed, transgenic mice given the human presenilin-1 (PS1) genewhich encodes one of the two subunits of -secretasewith one missense mutation (Val97Leu, PS1V97L) formed abundant A oligomers (Zhang et al., 2014), produced cognitive deficits, and exhibited cellular oxidative stress markers (Tian et al., 2019

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This does not change the genetic predisposition to produce keratin, but it may help the skin manage that protein more efficiently

Am J Obstet Gynecol MFM