However, the use of this medication requires a prolonged initial treatment period of dose-escalation to attenuate the adverse gastrointestinal effects (nausea, vomiting, diarrhea) typically associated with GLP-1R agonists, which still occurred frequently but rarely resulted in discontinuation of treatment
Such alterations were depicted as remarkable portal congestion, periportal inflammatory infiltrate, and moderate hepatocyte necrosis (nuclear pyknosis, karyorrhexis, and karyolysis with cytoplasmic eosinophilia), whereas the CTRL group exhibited normal architecture of liver tissue
Taken together, various cell death pathways exist that in physiological conditions take part in the fine processes of development, differentiation, and removal of damaged or unfunctional cells and subcellular structures, or harmful microorganisms
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