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The transmethylation axis: Methionine is the precursor for SAM (S-adenosylmethionine) the universal methyl donor that methylates DNA, histones, RNA, proteins, phospholipids, neurotransmitters, and numerous other metabolites

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Kidney failure and liver damage: Untill now, studies in patients with liver damage or renal failure did not detect pharmacokinetic differences, in normal individuals

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But it has a lot of therapeutic potential