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In hypothyroid patients, this mechanism addresses one of the core challenges: excess calorie intake due to blunted satiety signals

This is likely due to a combination of factors, including but not limited to little coverage of this topic in medical training pertaining to ME/CFS and comorbid conditions

Enzyme Activation: cAMP activates protein kinase A, which phosphorylates hormone-sensitive lipase and perilipin proteins surrounding lipid droplets

doi: 10.4049/jimmunol.0803576 452 HsiaoEYMcBrideSWHsienSSharonGHydeERMcCueTet al

Retrieved 17 May 2010

Degradation enhancement is caused mainly by the activation of the UPS (such as the increased expression of key factors MuRF1 and atrogin-1) and the autophagy-lysosome system (ALS), which together accelerate muscle protein degradation under oxidative stress [38]