The poly-dipeptides derived from C9ORF72 hexanucleotide expansions exhibit high affinity for mitochondrial proteins, thereby impairing mitochondrial structural integrity and intracellular transport dynamics, as well as Ca 2+ uptake and ATP synthesis (Fumagalli et al., 2021)
So, theres a lot of work happening trying to see whether we can get these drugs into the brain better
BPC 157, short for Body Protection Compound 157, is a synthetic peptide derived from a protein found in human gastric juice
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