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Junyu Zhao, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Dose escalation should follow licensed schedules to minimise gastrointestinal adverse effects

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Dosage adjustments, side effect management, and direct provider messaging are all included